SAB4504720

Anti-phospho-p16-INK4a (pSer¹⁵²) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): MTS1, Multiple tumor suppressor 1, p14ARF
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 17 kDa
• 종 반응성: human, rat, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:1000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: P42771
• UniProt 수납 번호: P42771
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer152)
• 유전자 정보: human ... CDKN2A(1029)

설명

일반 설명

p16INK4A (cyclin-dependent kinase inhibitor 2A isoform) and p14ARF (cyclin-dependent kinase inhibitor 2A) are encoded by the CDKN2A (cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor) gene. p16INK4A is a low molecular weight protein. This gene is mapped to human chromosome 9p21.

면역원

The antiserum was produced against synthesized peptide derived from human p16-INK4a around the phosphorylation site of Ser152.

Immunogen Range: 107-156

생화학적/생리학적 작용

p16INK4A (cyclin-dependent kinase inhibitor 2A isoform) serves as a tumor suppressor and it negatively modulates cell growth by arresting cells in the G1 phase. Mutations in the CDKN2A (cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor) gene is the main reason of inherited susceptibility to melanoma.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable