추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 151 kDa
종 반응성
human, rat, mouse
농도
~1 mg/mL
기술
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr1175)
유전자 정보
human ... KDR(3791)
관련 카테고리
일반 설명
The vascular endothelial growth factor receptor-2 (VEGFR-2) is also called as kinase insert domain containing receptor (KDR). There are seven immunoglobulin-like (Ig-like) domains at the extracellular region (EC) of VEGFR-2. This gene is mapped to human chromosome 4q12.
면역원
The antiserum was produced against synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1175.
Immunogen Range: 1141-1190
Immunogen Range: 1141-1190
애플리케이션
Anti-phospho-VEGFR2 (pTyr1175) antibody has been used in immunoblotting.
생화학적/생리학적 작용
The immunoglobulin-like (Ig-like) domains of the vascular endothelial growth factor receptor-2 (VEGFR-2) are essential for specific ligand binding and receptor dimerization. It helps to activate multiple signaling cascades. VEGF-KDR participates in angiogenesis. VEGFR2 is involved in progression of several cancers like gliomas, malignant peripheral nerve sheath tumors, triple-negative breast cancer (TNBC) and gastrointestinal stromal tumors (GISTs).
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
VEGF165b modulates endothelial VEGFR1-STAT3 signaling pathway and angiogenesis in human and experimental peripheral arterial disease.
Ganta VC, et al.
Circulation Research (2016)
Vijay Chaitanya Ganta et al.
Circulation research, 120(2), 282-295 (2016-12-16)
Atherosclerotic-arterial occlusions decrease tissue perfusion causing ischemia to lower limbs in patients with peripheral arterial disease (PAD). Ischemia in muscle induces an angiogenic response, but the magnitude of this response is frequently inadequate to meet tissue perfusion requirements. Alternate splicing
Immunoglobulin-like domain 4-mediated ligand-independent dimerization triggers VEGFR-2 activation in HUVECs and VEGFR2-positive breast cancer cells.
Zhang S, et al.
Breast Cancer Research and Treatment, 163(3), 423-434 (2017)
Vascular endothelial growth factor receptor-2 polymorphisms have protective effect against the development of tendinopathy in volleyball athletes.
Salles JI, et al.
PLoS ONE, 11(12), e0167717-e0167717 (2016)
The three receptor tyrosine kinases c-KIT, VEGFR2 and PDGFRα, closely spaced at 4q12, show increased protein expression in triple-negative breast cancer.
Jansson S, et al.
PLoS ONE, 9(7), e102176-e102176 (2014)
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