SAB4504326

Anti-phospho-Vitamin D Receptor (pSer²⁰⁸) antibody produced in rabbit

affinity isolated antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 48 kDa
• 종 반응성: mouse, rat, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI 수납 번호: P11473
• UniProt 수납 번호: P11473
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer208)
• 유전자 정보: human ... VDR(7421)

설명

일반 설명

VDR (vitamin D receptor) or vitamin D3 receptor is a member of the steroid and thyroid hormone receptors superfamily of trans-acting transcriptional regulatory factors. It is an intracellular polypeptide of 50-60 kDa. This receptor is composed of a highly conserved cysteine, lysine, and arginine-rich DNA-binding domain, and a hydrophobic ligand-binding domain in its C-terminal. It shares size and sequence similarity to thyroid hormone receptor. VDR gene is localized to human chromosome 12q12-q14.

면역원

The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor around the phosphorylation site of Ser208.

Immunogen Range: 181-230

생화학적/생리학적 작용

VDR (vitamin D receptor) binds with its ligand vitamin D3, and acts upon the target cell nuclei to induce various biological effects. Vitamin D3 is also thought to have immunomodulatory effects, and gene polymorphisms are linked with pertussis. The variants might affect the immune response and clinical outcome of Bordetella pertussis infection.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable