생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 69 kDa
종 반응성
human, mouse, rat
농도
~1 mg/mL
기술
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr292)
유전자 정보
human ... ZAP70(7535)
일반 설명
Zeta-chain-associated protein kinase 70 (ZAP70) is a tyrosine kinase, present in T cells and natural killer (NK) cells. It belongs to the spleen tyrosine kinase (Syk) family. This gene is mapped to human chromosome 2q11.
면역원
The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr292.
Immunogen Range: 258-307
Immunogen Range: 258-307
생화학적/생리학적 작용
Zeta-chain-associated protein kinase 70 (ZAP70) plays an important role in T cell receptor (TCR) signaling. It acts as an adaptor protein to increase BCR (B-cell receptor) signaling. This protein is required for T-cell transendothelial migration mediated by C-X-C motif chemokine ligand 12.
특징 및 장점
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물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.
Shah NH, et al.
eLife, 5, e20105-e20105 (2016)
The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system
Alsadeq A, et al.
Haematologica, 102(2), 346-355 (2017)
Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype
Paloneva J, et al.
American Journal of Human Genetics, 71(3), 656-662 (2002)
Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor
Li K, et al.
Annals of Biomedical Engineering, 44(12), 3510-3521 (2016)
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