SAB4503840

Anti-phospho-WNK1 (pThr⁵⁸) antibody produced in rabbit

affinity isolated antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 250 kDa
• 종 반응성: rat, human, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: Q9H4A3
• UniProt 수납 번호: Q9H4A3
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pThr58)
• 유전자 정보: human ... WNK1(65125)

설명

일반 설명

The WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The encoded protein belongs to the WNK kinase family and is ubiquitously expressed.

면역원

The antiserum was produced against synthesized peptide derived from human WNK1 around the phosphorylation site of Thr58.

Immunogen Range: 24-73

생화학적/생리학적 작용

WNK1 (WNK lysine deficient protein kinase 1) is responsible for maintaining the ion homeostasis. It regulates mitogen-activated protein kinase 7 (MAPK7) mediated cell proliferation and migration. It is also known to promote tumor proliferation, invasion and metastasis in prostate carcinoma. WNK1 expression is essential for vascular remodeling and endothelial sprouting. Autophagy has been indicated in various diseases. This intracellular degradation pathway is prevented by WNK1.(3)

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable