추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 72 kDa
종 반응성
mouse, rat, human
농도
~1 mg/mL
기술
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr525)
유전자 정보
human ... SYK(6850)
관련 카테고리
일반 설명
Spleen tyrosine kinase (SYK) is a member of the non-receptor tyrosine kinase family. It is usually expressed in epithelial breast tissues and hematopoietic cells. SYK is mapped to human chromosome 9q22.
면역원
The antiserum was produced against synthesized peptide derived from human SYK around the phosphorylation site of Tyr525.
Immunogen Range: 491-540
Immunogen Range: 491-540
애플리케이션
Anti-phospho-SYK (pTyr525) antibody has been used in immunohistochemistry.
생화학적/생리학적 작용
Spleen tyrosine kinase (SYK), as a tumor suppressor gene helps to prevent the development and metastasis of breast cancer cells. It participates in B-cell receptor signaling. This protein helps to phosphorylate the α-tubulin subunits of microtubules.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma
Sun H, et al.
Clinical Cancer Research, 23(15), 4376-4387 (2017)
Conny Tümmler et al.
Cancers, 11(2) (2019-02-13)
Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine
Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma
Rinaldi A, et al.
British Journal of Haematology, 132(3), 303-316 (2006)
Novel SYK gene variations and changes in binding sites of miRs in breast cancer patients
Faryal R, et al.
Cancer Biomarkers : Section A of Disease Markers, 16(3), 319-326 (2016)
Haibo Sun et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(15), 4376-4387 (2017-03-25)
Purpose: Ewing sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TK) and associated pathways are continuously activated in many malignancies, including EWS; these enzymes provide candidate therapeutic targets.Experimental Design: Two high-throughput screens (a siRNA
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