추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 25 kDa
종 반응성
mouse, human, rat
농도
~1 mg/mL
기술
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TNF(7124)
일반 설명
Anti-TNFA Antibody detects endogenous levels of total TNFA protein.
The TNFA (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33 and codes for a pro-inflammatory cytokine.
면역원
The antiserum was produced against synthesized peptide derived from human TNFA.
Immunogen Range: 141-190
Immunogen Range: 141-190
생화학적/생리학적 작용
The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Roosmarijn E Vandenbroucke et al.
EMBO molecular medicine, 5(7), 1000-1016 (2013-06-01)
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases. We observed that MMP13(-/-) mice display a strong protection
Inflammatory cytokine production in tumor cells upon chemotherapy drug exposure or upon selection for drug resistance
Edwardson D.W
PLoS ONE, 12(9), 1-32 (2017)
Máté Bencsics et al.
Frontiers in immunology, 14, 1135410-1135410 (2023-07-17)
T cell-dependent inflammatory response with the upregulation of helper 17 T cells (Th17) and the downregulation of regulatory T cells (Treg) accompanied by the increased production of tumor necrosis alpha (TNFa) is characteristic of inflammatory bowel diseases (IBD). Modulation of
Syndecan-4 in intervertebral disc and cartilage: Saint or Synner?
Binch ALA
Matrix Biology, 52-54, 355-362 (2016)
Seyed K Tayebati et al.
CNS & neurological disorders drug targets, 15(8), 995-1000 (2016-05-31)
Spontaneously hypertensive rats (SHR) represent a model of hypertension and vascular injury. In the past decade, SHR were also considered as a model of vascular dementia. Several studies have shown that cerebrovascular changes in SHR may mimic brain vascular diseases
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