SAB4502971

Anti-TIMP1 antibody produced in rabbit

affinity isolated antibody

• 동의어(들): COLLAGENASE INHIBITOR, EPA, HCI, HUMAN, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
• MDL number: MFCD01322705
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 23 kDa
• 종 반응성: mouse, human, rat
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI 수납 번호: P01033
• UniProt 수납 번호: P01033
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TIMP1(7076)

설명

일반 설명

The TIMP1 (TIMP metallopeptidase inhibitor 1) gene is mapped to human chromosome Xp11.3.

Tissue inhibitors of metalloproteinase 1 (TIMP1) is a member of TIMPs protein family. It is widely expressed in most of the human tissues and body fluids. TIMP1 is a wedge shaped protein with five β-strands, a central helical region representing the interface of the two domains and a C-terminal β-structure.

면역원

The antiserum was produced against synthesized peptide derived from human TIMP1.

Immunogen Range: 61-110

애플리케이션

Anti-TIMP1 antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

TIMP1 (TIMP metallopeptidase inhibitor 1) mediates the communication between tumor cells and cancer associated fibroblasts and contributes to tumor progression in condition such as hepatocellular carcinoma. The encoded protein is a cytokine tissue inhibitor. Timp1 regulates the activity of matrix metalloproteinases (MMP) especially MMP-8 and -9. Imbalance in Timp1 levels lowers the fibrotic material in the extracellular matrix and results in inflammation. This might contribute to the pathogenesis of myocardial fibrosis, atherosclerosis and acute coronary syndrome. Timp1 level serves as an important biomarker in the development of sepsis.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable