추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 35 kDa
종 반응성
rat, mouse, human
농도
~1 mg/mL
기술
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MNAT1(4331)
일반 설명
Anti-MAT1 Antibody detects endogenous levels of total MAT1 protein. CDK activating kinase assembly factor MNAT1 or MAT1 enzyme is encoded by the MNAT1 gene in humans and is localized to chromosome 14q23. The protein is part of the cyclin-dependent kinase-activating kinase complex.
면역원
The antiserum was produced against synthesized peptide derived from human MAT1.
Immunogen Range: 91-140
Immunogen Range: 91-140
생화학적/생리학적 작용
CDK activating kinase assembly factor MNAT1 or MAT1 is functionally associated with the general transcription/DNA repair factor TFIIH. It is an assembly factor that targets subunits of both cyclin-dependent kinase-activating kinase (CAK) and TFIIH kinase. MAT1 regulates cell cycle and transcription. This protein associates with cyclin H and cyclin-dependent kinase 7 (CDK7) and forms the CDK-activating kinase (CAK) complex. The complex activates several cyclin-associated kinases, regulates cell cycle progression and activates RNA polymerase II-mediated transcription.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family
V Gervais
The Journal of Biological Chemistry, 276 (2000)
Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha
Jiwei Wang
The Journal of Biological Chemistry, 277 (2002)
The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts
Siyue Lou
Stem Cells (2013)
Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively
Eki T
Genomics, 47(1) (1998)
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