일반 설명
Anti-KIT Antibody detects endogenous levels of total KIT protein.
KIT (proto-oncogene) is a type III receptor tyrosine kinase (RTK). It codes for a tyrosine kinase receptor (CD117). It is located on human chromosome 4q12.
면역원
The antiserum was produced against synthesized peptide derived from human KIT.
Immunogen Range: 906-955
Immunogen Range: 906-955
생화학적/생리학적 작용
KIT (proto-oncogene) participates in cell signal transduction. It also participates in the progression of hematopoietic stem cells, melanocytes, germ cells, mast cells and interstitial cells of Cajal. Mutations in KIT gene results in gastrointestinal stromal tumors.
특징 및 장점
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물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Yu Wang et al.
Cell communication and signaling : CCS, 16(1), 16-16 (2018-04-18)
Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis. miRNA microarray analysis and real-time PCR were used to determine the miRNA expression profiles in
Loss of c-KIT expression in thyroid cancer cells.
Franceschi S, et al.
PLoS ONE, 12(3) (2017)
KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
Lux ML, et al.
The American Journal of Pathology, 156(3), 791-795 (2000)
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