추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 105 kDa
종 반응성
mouse, human, rat
농도
~1 mg/mL
기술
ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... GRIN1(2902)
일반 설명
N-methyl-d-aspartate receptor (NMDAR1) is a subtype of the ionotropic glutamate receptors (iGluRs). It is coded by GRIN1 gene. It is located on human chromosome 9q34.3. NMDAR1is expressed in epidermal melanocytes.
Anti-NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.
면역원
The antiserum was produced against synthesized peptide derived from human NMDAR1.
Immunogen Range: 856-905
Immunogen Range: 856-905
애플리케이션
Anti-NMDAR1, C-Terminal antibody has been used in western blot analysis.
생화학적/생리학적 작용
N-methyl-d-aspartate receptor (NMDAR1) plays an important role in the pathophysiology of schizophrenia, bipolar disorder and depression. Mutations in GRIN1 gene results in severe intellectual disability, hypotonia, hyperkinetic and stereotyped movements, and epilepsy.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy
Zehavi Y, et al.
European Journal of Medical Genetics, 60(6), 317-320 (2017)
Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder
Mundo E, et al.
Molecular Psychiatry, 8(2), 241-241 (2003)
Xin Liu et al.
American journal of physiology. Cell physiology, 313(2), C187-C196 (2017-06-02)
Major depression is an important clinical factor in ventricular arrhythmia. Patients diagnosed with major depression overexpress N-methyl-d-aspartate receptors (NMDARs). Previous studies found that chronic NMDAR activation increases susceptibility to ventricular arrhythmias. We aimed to explore the mechanisms by which NMDAR
The effect of the NMDA receptor-dependent signaling pathway on cell morphology and melanosome transfer in melanocytes
Ni J, et al.
Journal of Dermatological Science, 84(3), 296-304 (2016)
The activation of N-methyl-d-aspartate receptors downregulates transient outward potassium and L-type calcium currents in rat models of depression
Liu X, et al.
American Journal of Physiology. Cell Physiology, 313(2), C187-C196 (2017)
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