SAB4500500

Anti-CSFR antibody produced in rabbit

affinity isolated antibody

• 동의어(들): CD115, CSF-1-R, CSF1R, CSFMR, c-fms
• MDL number: MFCD00282160
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 107 kDa
• 종 반응성: human, rat, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• NCBI 수납 번호: P07333
• UniProt 수납 번호: P07333
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CSF1R(1436)

설명

일반 설명

Colony stimulating factor 1 receptor (CSF-1R) is encoded by the c-fms proto-oncogene mapped to human chromosome 5q33. The encoded protein acts as a receptor for CSF1 expressed in non-hematopoietic cells, such as macrophages, epithelial and fibroblasts cells and tumor cells.

면역원

The antiserum was produced against synthesized peptide derived from human CSFR.

Immunogen Range: 531-580

생화학적/생리학적 작용

Colony stimulating factor 1 receptor (CSF-1R)/ CSF-1 ligand system plays a vital role in the regulation of macrophage physiology in immune system.The encoded protein functions as a receptor and mediates the function of its ligand, colony stimulating factor 1, a cytokine involved in regulation of production, differentiation, and function of macrophages. Experimental analysis revealed that CSF-1/CSF-1R is overexpressed in patients with nasopharyngeal carcinoma when compared to patients with nasopharyngitis. Activated CSF-1R, is essential for monocyte differentiation to macrophages by oxidized low-density lipoprotein (Ox-LDL), which is a vital step in early atherogenesis. This protein is also associated with regulation of hematopoiesis. Deletion or mutation of this gene might be involved in the pathogenesis of myelodysplastic syndromes or of acute nonlymphocytic leukemia (ANLL).

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable