SAB4301113

Anti-RAS antibody produced in rabbit

affinity isolated antibody

• 동의어(들): CTLO, HAMSV, HRAS1, K-RAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: 21 kDa
• 종 반응성: mouse, rat, human
• 농도: 0.7 mg/mL
• 기술: western blot: 1:200-1:1000 (Cell Lysate)
• 동형: IgG
• 수납 번호(accession number): NP_001123914.1
• UniProt 수납 번호: P01112
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... HRAS(3265)

설명

일반 설명

Ras is a proto-oncogene and the gene encoding it is localized on human chromosome 11p15.5. It is a 21 kDa protein and is part of the small GTP-binding proteins superfamily.

특이성

The antibody detects endogenous level of total RAS protein.

면역원

Synthetic peptide corresponding to a region derived from 60-74 amino acids of Human v-Ha-ras Harvey rat sarcoma viral oncogene homolog

생화학적/생리학적 작용

Ras is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable