생물학적 소스
rabbit
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
human
농도
2.9 mg/mL
기술
immunohistochemistry: 1:25- 1:100
동형
IgG
수납 번호(accession number)
NP_004235.4
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CD163(9332)
일반 설명
Cluster of differentiation 163 (CD163) is a hemoglobin scavenger receptor, encoded by a gene mapped to human chromosome 12p13.31. It is expressed on the surface of activated macrophages. The encoded protein is a member of scavenger receptor cysteine-rich family (SRCR) and is specifically expressed on cells of the monocyte/macrophage lineage.
특이성
The antibody detects endogenous levels of total CD163 protein.
면역원
Synthetic peptide corresponding to residues near the C terminal of human CD163 molecule
생화학적/생리학적 작용
Cluster of differentiation 163 (CD163) modulates anti-inflammatory functions and has a role in hemoglobin-haptoglobin clearance. Various cytokines influence the expression of CD163. It may be associated with hepatocellular carcinoma. Soluble CD163 level in serum acts as a potent indicator of the progression of cirrhosis and portal hypertension.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease.
Enomoto Y, et al.
Arthritis Research & Therapy, 19(1), 9-9 (2017)
SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis.
Constantine C C, et al.
BMC Medical Genetics, 9(1), 18-18 (2008)
Role of Serum Soluble CD163 in the Diagnosis, Risk of Bleeding, and Prognosis of Gastro-Esophageal Varices in Cirrhotic Patients.
Fouad R, et al.
Journal of Interferon & Cytokine Research, 37(3), 112-118 (2017)
Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma.
Kazankov K, et al.
Scandinavian Journal of Clinical and Laboratory Investigation, 76(1), 64-73 (2016)
C Buechler et al.
Journal of leukocyte biology, 67(1), 97-103 (2000-01-27)
CD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among
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