추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
HP-6014, monoclonal
형태
buffered aqueous solution
종 반응성
human
농도
~1.0 mg/mL
기술
immunofluorescence: suitable
indirect ELISA: 0.07-0.15 μg/mL using 1 μg/mL Human IgG2 myeloma for coating
동형
IgG1
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
관련 카테고리
일반 설명
Anti-Human IgG2 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the HP-6014 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgG2 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads. Human IgG consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5, and 4% of the total IgG, respectively.
면역원
Purified human IgG2 myeloma protein
애플리케이션
Anti-Human IgG2 antibody, Mouse monoclonal may be used in immunological techniques, including enzyme linked immunosorbent assay (ELISA), immunofluorescence, hemagglutination (HA) and hemagglutination inhibition.
생화학적/생리학적 작용
Lipopolysaccharides stimulate an IgG2 response in peripheral blood leukocytes (PBL) and an IgG1 response in the spleen. Only IgG1 and IgG3 are capable of adherence to mononuclear phagocytes while IgG2 and IgG4 autoantibodies are much less efficient. The amount of the different IgG subclasses present in the blood shows variation with age. For example, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels raise more slowly, reaching adult levels at about 10 years of age. Serum IgG subclass deficiencies have been recorded for different patient groups. For example, IgG2 and IgG4 deficiency is found in patients of ataxia telangiectasia. Low IgG2 levels were found in patients with Systemic lupus erythematosus (SLE) and juvenile diabetes mellitus.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Immunodeficiency and infections in ataxia-telangiectasia
Nowak-Wegrzyn A, et al.
The Journal of Pediatrics, 144(4), 505-511 (2004)
Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood
Blanco E, et al.
The Journal of Allergy and Clinical Immunology, 141(6), 2208-2219 (2018)
Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy
Scott-Taylor TH, et al.
Immunity, inflammation and disease, 6, 13-33 (2018)
Effect of anti-epileptic drugs on serum level of IgG subclasses
Ashrafi MR, et al.
Iranian journal of pediatrics, 20(3), 269-269 (2010)
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