SAB4200565

Monoclonal Anti-ZFP36/TTP antibody produced in mouse

clone TTP6, tissue culture supernatant

• 동의어(들): Anti-G0/G1 switch regulatory protein 24, Anti-G0S24, Anti-Growth factor-inducible nuclear protein NUP475, Anti-NUP475, Anti-RNF162A, Anti-TIS11, Anti-TIS11A, Anti-Zinc finger protein 36 homolog, Anti-tristetraprolin, Anti-zinc finger protein 36, C3H type, homolog (mouse), Anti-zinc finger protein, C3H type, 36 homolog (mouse)
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: tissue culture supernatant
• 항체 생산 유형: primary antibodies
• 클론: TTP6, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~45 kDa
• 종 반응성: mouse, bovine, rat, dog, human, monkey
• 기술: western blot: 1:4,000-1:8,000 using extracts of HepG2 cells.
• UniProt 수납 번호: P26651
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ZFP36(7538)

설명

일반 설명

Monoclonal Anti-ZFP36/TTP (mouse IgM isotype) is derived from the hybridoma TTP6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal sequence of human ZFP36/TTP, conjugated keyhole limpet hemocyanin (KLH). ZFP36 (also known as tristetraprolin or TTP) is a RNA-binding protein. It belongs to the RNA-binding zinc-finger protein family. TTP consists of a cysteine-cysteine-cysteine-histidine (CCCH) zinc finger motif and uridine-rich elements (AREs) in the 3′ untranslated region (3′ UTR) of target mRNA. This gene is located on human chromosome 19q13.1.

면역원

a peptide corresponding to an internal sequence of human ZFP36/TTP conjugated KLH.

애플리케이션

Monoclonal Anti-ZFP36/TTP antibody has been used in immunoblotting.

생화학적/생리학적 작용

ZFP36 (also known as tristetraprolin or TTP) participates in controlling the expression of AU-rich element (ARE) -containing mRNAs. It participates in accelerating mRNA decay. ZFP36 was found to limit the expression of a number of critical genes frequently overexpressed in inflammation and cancer. It also plays a major role in differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis and immunity.

물리적 형태

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3