SAB4200425

Anti-COG1 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 동의어(들): Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect B complementing
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~110 kDa
• 종 반응성: rat, mouse, human
• 농도: ~1.0 mg/mL
• 기술: western blot: 2.5-5.0 μg/mL using whole extracts of human HepG2 and rat PC12 cells.
• UniProt 수납 번호: Q8WTW3
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... COG1(9382) ; mouse ... Cog1(16834) ; rat ... Cog1(303652)

설명

일반 설명

The conserved oligomeric Golgi complex 1 (COG1) protein is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex contains eight subunits organized in two heterotrimeric groups, COG-2-COG3-COG4 and COG5-COG6-COG7, which are linked by the dimeric group formed by COG1 and COG8. The COG1 gene is located on the human chromosome at 17q25.1.

특이성

Anti-COG1 (N-terminal) recognizes human and rat COG1.

면역원

peptide corresponding to the N-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and bovine COG1.

애플리케이션

Anti-COG1 (N-terminal) antibody produced in rabbit may be used in immunoblotting.

생화학적/생리학적 작용

The conserved oligomeric Golgi complex 1 (COG1) protein is needed for normal Golgi function. It is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates. It also plays a role in the organization of the Golgi-localized complex. In humans, mutations in the COG subunit cause novel types of congenital disorders of glycosylation.

물리적 형태

solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

저장 및 안정성

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

면책조항

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable