SAB4200358

Anti-PLAUR antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 동의어(들): Anti-CD87, Anti-U-PAR, Anti-UPAR, Anti-URKR, Anti-Urokinase receptor, Anti-plasminogen activator
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 45/50 kDa
• 종 반응성: human
• 농도: ~1.0 mg/mL
• 기술: indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells over-expressing human PLAUR.
• UniProt 수납 번호: Q03405
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PLAUR(5329)

설명

일반 설명

Plasminogen activator urokinase receptor (PLAUR)/ urokinase plasminogen activator receptor (uPAR), a member of Ly6/ neurotoxin receptor family, is a heavily glycosylated glycosyl-phosphatidylinositol (GPI)-anchored cell-surface receptor. It is comprised of serine protease uPA, specific inhibitors (plasminogen activator inhibitors 1 and 2) and three internally disulfide-bonded domains (D1, D2 and D3).

면역원

peptide corresponding to a sequence at the C-terminus of human PLAUR, conjugated to KLH. The corresponding sequence is identical in monkey PLAUR.

애플리케이션

Anti-PLAUR antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

생화학적/생리학적 작용

Plasminogen activator urokinase receptor (PLAUR)/ urokinase plasminogen activator receptor (uPAR) acts as a receptor for urokinase plasminogen activator (uPA). It localizes and promotes plasmin formation. uPAR influences many normal and pathological processes related to cell surface plasminogen activation, degradation of the extracellular matrix, cell migration, leukocyte adhesion, chemotaxis and signal transduction during leukocyte recruitment from the circulation to extravascular sites of inflammation. It is implicated as an anti-cancer target. uPAR is involved in epilepsy, language, cognition, communication and central nervous system disorders.

물리적 형태

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable