추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen ~123 kDa
종 반응성
human
농도
~1.0 mg/mL
기술
immunoprecipitation (IP): 2.5-5.0 μg using lysates of human HEK-293 cells.
indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293 cells overexpressing human Importin 5.
western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... IPO5(3843)
mouse ... Ipo5(70572)
rat ... Ipo5(306182)
일반 설명
In human cells, there are more than 20 members of the importins/exportins family. Importin-5 (IPO5) belongs to the importin-β superfamily and is mapped to human chromosome 13q32.2.
애플리케이션
Anti-Importin 5 (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
생화학적/생리학적 작용
Nucleocytoplasmic transport of proteins and RNAs is mediated through nuclear pore complexes (NPCs) and by karyopherins nuclear transport receptors (importins/exportins). Importins mediate either the nuclear import of a very diverse set of protein or RNA cargoes. The function of importins are regulated by the Ran G protein. Ran G protein stimulates the release of cargo from importins. Importins are implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation
Clerman A, et al.
The Journal of biological chemistry, 292(52), 21653-21661 (2017)
Genome-wide association study of peripheral arterial disease in a Japanese population
Matsukura M, et al.
Testing, 10(10), e0139262-e0139262 (2015)
Pauline J van der Watt et al.
International journal of cancer, 150(2), 347-361 (2021-10-01)
Previous studies have identified increased expression of members of the nuclear transport protein family in cancer cells. Recently, certain nuclear transport proteins have been reported to be secreted by cells and found in the serum. The aims of our study
Structural biology of nucleocytoplasmic transport
Cook A, et al.
Annual Review of Biochemistry, 76(3), 647-671 (2007)
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
Jakel S, et al.
The Embo Journal, 21(3), 377-386 (2002)
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