SAB3500661

Anti-VKORC1 antibody produced in rabbit

affinity isolated antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 분자량: 18 kDa
• 종 반응성: mouse, human
• 농도: 1 mg/mL
• 기술: ELISA: suitable; western blot: suitable
• NCBI 수납 번호: NP_076869
• UniProt 수납 번호: Q9BQB6
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... VKORC1(79001)

설명

일반 설명

Vitamin K epoxide reductase complex subunit 1 (VKORC1), also known as vitamin K clotting factor deficiency type 2 (VKCFD2), is an integral, 163-amino acid long transmembrane protein. It is encoded by the gene mapped to a 20Mb region on human chromosome 16p12–q21. VKORC1 is widely expressed in various tissues and organs.

면역원

Antibody was raised against a 15 amino acid peptide near the amino terminus of human VKORC1.

생화학적/생리학적 작용

Vitamin K epoxide reductase complex subunit 1 (VKORC1) enzyme plays a vital role in vitamin K cycle. It catalyzes the conversion of inactive vitamin K to vitamin K hydroquinone, which is crucial for the post-translational γ-carboxylation of vitamin K–dependent clotting factors II (prothrombin), VII, IX, and X. VKORC1 acts as a key target for oral anticoagulants and is also involved in drug metabolism.{4} Genetic variation in the gene leads to warfarin resistance and multiple coagulation factor deficiency type 2.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

결합

The action of this antibody can be blocked using blocking peptide SBP3500661.

물리적 형태

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable