SAB3500093

Anti-JMJD1A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-JHDM2A, Anti-JHMD2A, Anti-KDM3A, Anti-Lysine-specific demethylase 3A, Anti-TSGA
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: predicted mol wt 145 kDa
• 종 반응성: human, mouse, rat
• 기술: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI 수납 번호: NP_060903
• UniProt 수납 번호: Q9Y4C1
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KDM3A(55818)

설명

일반 설명

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.

면역원

JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

생화학적/생리학적 작용

Jumonji domain containing 1A protein (JMJD1A) is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of signal transducer and activator of transcription 3 (STAT3), a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells. Decreased JMJD1A expression is correlated with the differentiation of cultured mES cells following the removal of the cytokine leukemia inhibitory factor (LIF). These findings suggest that JMJD1A might be a signaling molecule having a role in maintaining pluripotency in embryonic stem cells.

특징 및 장점

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결합

The action of this antibody can be blocked using blocking peptide SBP3500093.

물리적 형태

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable