추천 제품
생물학적 소스
goat
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
canine, bovine, human, rat, mouse
기술
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... ZCCHC11(23318)
일반 설명
Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.
면역원
Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1
생화학적/생리학적 작용
Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Molecular similarity between myelodysplastic form of chronic
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
Veronique Gelsi-Boyer
Haematologica (2012)
Identification of small molecule inhibitors of Zcchc11 TUTase activity.
Lin S and Gregory RI
RNA Biology, 12(8), 792-800 (2015)
Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, et.al
Nature Cell Biology, 11(9), 1157-1163 (2009)
Matthew R Jones et al.
Nature cell biology, 11(9), 1157-1163 (2009-08-25)
Mounting an effective host immune response without incurring inflammatory injury requires the precise regulation of cytokine expression. To achieve this, cytokine mRNAs are post-transcriptionally regulated by diverse RNA-binding proteins and microRNAs (miRNAs) targeting their 3' untranslated regions (UTRs). Zcchc11 (zinc-finger
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