추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
133 kDa
종 반응성
human
농도
0.5 mg - 1 mg/mL
기술
western blot: suitable
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... AFF3(3899)
일반 설명
AF4/FMR2 family member 3 (AFF3), a tissue-restricted nuclear transcriptional activator, is mainly expressed in the lymphoid tissue. This RNA binding protein is a member of the AF4/LAF4/FMR2/AF5q31 family. AFF3 is a component of the transcriptional super elongation complex. It is expressed at a high level in the thymus. AFF3 has two domains with transactivation activity. This lymphoid-specific gene, is located on the human chromosome 2q11.2.
면역원
Synthetic peptide directed towards the middle region of human AFF3
생화학적/생리학적 작용
AF4/FMR2 family member 3 (AFF3) participates in transcriptional regulation. It is a potential clinical modulator of estrogen receptor (ER) signaling. This transcription activator can play a role in lymphoid development and cancer. It can bind to double-stranded DNA in vitro. AFF3 overexpression causes tamoxifen resistance and estrogen-independent proliferation in ER+ human breast tumors.
서열
Synthetic peptide located within the following region: APATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD
물리적 형태
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
AFF3 (lymphoid nuclear protein related to AF4)
Bergh ARM Von
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2003)
Yawei Shi et al.
Journal of experimental & clinical cancer research : CR, 37(1), 254-254 (2018-10-18)
Although tamoxifen is a highly effective drug for treating estrogen receptor-positive (ER+) breast cancer, nearly all patients with metastasis with initially responsive tumors eventually relapse, and die from acquired drug resistance. Unfortunately, few molecular mediators of tamoxifen resistance have been
A Ruyssen-Witrand et al.
Tissue antigens, 80(2), 105-118 (2012-07-28)
Rheumatoid arthritis (RA) is a common autoimmune disease with a strong genetic component. Numerous aberrant immune responses have been described during the evolution of the disease. In later years, the appearance of anti-citrullinated protein antibodies (ACPAs) has become a hallmark
Norine Voisin et al.
American journal of human genetics, 108(5), 857-873 (2021-05-08)
The ALF transcription factor paralogs, AFF1, AFF2, AFF3, and AFF4, are components of the transcriptional super elongation complex that regulates expression of genes involved in neurogenesis and development. We describe an autosomal dominant disorder associated with de novo missense variants
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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