SAB1407028

Anti-ARID3B antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• 동의어(들): BDP, DRIL2
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~27.8 kDa
• 종 반응성: human
• 기술: indirect immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI 수납 번호: BC060824
• UniProt 수납 번호: Q8IVW6
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ARID3B(10620)

설명

일반 설명

AT-rich interaction domain 3B (ARID3B) is encoded by the gene mapped to human chromosome 15q24.1. It is mainly expressed in leukocytes, placenta and testis. ARID3B belongs to the AT-rich interaction domain (ARID) family of proteins.

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. (provided by RefSeq)

면역원

ARID3B (AAH60824.1, 1 a.a. ~ 253 a.a) full-length human protein.

Sequence
MEPLQQQQQQQQQQQKQPHLAPLQMDAREKQGQQMREAQFLYAQKLVTQPTLLSATAGRPSGSTPLGPLARVPPTAAVAQVFERGNMNSEPEEEDGGLEDEDGDDEVAEVAEKETQAASKYFHVQKVARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKDASKASPSVSTAGQPNWNLDEQLKQNGGLAWSDDADGGRGREISRDFAKLYELDGDPERKEFLDDLFVFMQKRGECASTHHSNSGNTDRVPTVC

생화학적/생리학적 작용

AT-rich interaction domain 3B (ARID3B) plays a vital role in the survival of neural crest during embryogenesis. It is involved in the pathogenesis of malignant neuroblastoma. ARID3B also facilitates the expression of pro-apoptotic p53-target genes and apoptosis.

물리적 형태

Solution in phosphate buffered saline, pH 7.4

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable