추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
58797 Da
종 반응성
human
기술
immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... APCDD1(147495)
일반 설명
Adenomatosis polyposis coli down-regulated 1 (APCDD1) encodes a membrane bound glycoprotein. Apcdd1 is predominantly expressed in epidermal and dermal compartments of human hair follicles. In human chromosome, the gene APCDD1 is localized on 18p11.22.
생화학적/생리학적 작용
Adenomatosis polyposis coli down-regulated 1 (APCDD1) inhibits wnt (wingless/integrated) signalling and promotes human hair growth. Mutations in APCDD1 results in a rare autosomal dominant hereditary hypotrichosis, which is characterized by hair loss due to hair follicle miniaturization. APCDD1 is directly regulated by β-catenin/T-cell factor 4 (TCF4). The high expression of Apcdd1 in colon cancer cells promotes its proliferation. APCDD1 is essential for adipocyte differentiation. Downregulation of APCDD1 in diet induced obesity impairs adipocyte differentiation and causes obesity related metabolic diseases.
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Novel role for Wnt inhibitor APCDD1 in adipocyte differentiation: implications for diet-induced obesity
Yiew NKH, et al.
The Journal of Biological Chemistry, jbc-M116 (2017)
Meiko Takahashi et al.
Cancer research, 62(20), 5651-5656 (2002-10-18)
To clarify the molecular mechanisms of human carcinogenesis associated with abnormal beta-catenin/T-cell factor (Tcf) signaling, we have been using cDNA microarrays to search for genes whose expression is significantly altered after introduction of wild-type APC into SW480 colon cancer cells.
Yutaka Shimomura et al.
Nature, 464(7291), 1043-1047 (2010-04-16)
Hereditary hypotrichosis simplex is a rare autosomal dominant form of hair loss characterized by hair follicle miniaturization. Using genetic linkage analysis, we mapped a new locus for the disease to chromosome 18p11.22, and identified a mutation (Leu9Arg) in the adenomatosis
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