추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
92670 Da
종 반응성
human, mouse
기술
immunofluorescence: 1:10-1:50
immunohistochemistry: 1:10-1:50
western blot: 1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... HIF1A(3091)
일반 설명
Hypoxia-inducible factor-1 (HIF1) is a transcription factor expressed in mammalian cells when cultured under reduced oxygen tension. HIF1 is a heterodimer composed of an α subunit and a β subunit. The β subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains. The gene encoding it is localized on human chromosome 14q23.2.
생화학적/생리학적 작용
Hypoxia-inducible factor-1 (HIF1) plays an essential role in cellular and systemic homeostatic responses to hypoxia. During hypoxia, the two subunits of this factor undergo post-translational modifications, which in turn promote transactivation. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. HIF-1α is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF).
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Regulation of Hypoxia-Inducible Factor 1a Expression and Function by the Mammalian Target of Rapamycin
Christine C, et al.
Molecular and Cellular Biology (2002)
Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia
The Yale Journal of Biology and Medicine (2007)
Multiple Gastrointestinal Stromal and Other Tumors Caused by Platelet-Derived Growth Factor Receptor a Gene Mutations: A Case Associated with a Germline V561D Defect
Barbara Pasini, et al.
The Journal of Clinical Endocrinology and Metabolism (2007)
Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model
Xihua Chen, et al.
Human Reproduction (2015)
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