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Merck
모든 사진(1)

Key Documents

S8939

Sigma-Aldrich

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

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About This Item

MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.32

재조합

expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)

Quality Level

형태

buffered aqueous solution

분자량

~48 kDa by SDS-PAGE

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... SGK1(6446)

일반 설명

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

생화학적/생리학적 작용

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.
Kinase assays.

단위 정의

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

물리적 형태

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

법적 정보

Brij is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids


시험 성적서(COA)

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문서 라이브러리 방문

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
Feng Hong
Molecular Cell, 30(6) (2011)
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition.
Talarico C
Cellular Physiology and Biochemistry (2016)
Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables
David W Ellison
Journal of Clinical Oncology (2011)
Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.
Ferrelli F
Acta Diabetologica (2015)

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