S8939

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

• MDL number: MFCD03458482
• UNSPSC 코드: 51111800
• NACRES: NA.32

속성

• 재조합: expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
• Quality Level: 200
• 형태: buffered aqueous solution
• 분자량: ~48 kDa by SDS-PAGE
• UniProt 수납 번호: O00141
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... SGK1(6446)

설명

일반 설명

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

생화학적/생리학적 작용

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.

Kinase assays.

단위 정의

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

물리적 형태

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

법적 정보

Brij is a registered trademark of Croda International PLC

안전성 정보

• Storage Class Code: 10 - Combustible liquids