재조합
expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
Quality Level
형태
buffered aqueous solution
분자량
~48 kDa by SDS-PAGE
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... SGK1(6446)
일반 설명
The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.
생화학적/생리학적 작용
The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.
Kinase assays.
단위 정의
One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.
물리적 형태
Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.
법적 정보
Brij is a registered trademark of Croda International PLC
Storage Class Code
10 - Combustible liquids
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
Molecular Cell, 30(6) (2011)
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition.
Cellular Physiology and Biochemistry (2016)
Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables
Journal of Clinical Oncology (2011)
Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.
Acta Diabetologica (2015)
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