R8756

Resiniferatoxin

from Euphorbia poisonii, ~95%

• 실험식(Hill 표기법): C₃₇H₄₀O₉
• CAS Number: 57444-62-9
• Molecular Weight: 628.71
• Beilstein: 5371150
• MDL number: MFCD00135927
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899411

속성

• 생물학적 소스: Euphorbia poisonii
• Quality Level: 100
• 분석: ~95%
• 저장 온도: −20°C
• SMILES string: [H][C@@]12C=C(C)C(=O)[C@@]1(O)CC(COC(=O)Cc3cc(O)cc(OC)c3)=CC4[C@H]5O[C@]7(Cc6ccccc6)O[C@]5(C[C@@H](C)[C@]24O7)C(C)=C
• InChI: 1S/C37H40O9/c1-21(2)35-17-23(4)37-29(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)11-22(3)32(34)40)20-43-31(39)15-25-12-27(38)16-28(13-25)42-5/h6-14,16,23,29-30,33,38,41H,1,15,17-20H2,2-5H3/t23-,29?,30-,33-,34-,35-,36-,37-/m1/s1
• InChI key: IKYCZSUNGFRBJS-PMIKMUNESA-N
• 유전자 정보: rat ... Trpv1(83810)

설명

애플리케이션

Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):

• for complex preparation for cryo-electron microscopy structural studies
• to test its effect towards immune responses to P. aeruginosa in sensory neurons associated with the cornea
• to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice

생화학적/생리학적 작용

Potent VR1 vanilloid receptor agonist that has been used to label the vanilloid receptor in sensory ganglia; activates protein kinase C. Diterpene ester that is related to phorbol, but is not tumorigenic.

Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance. It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF).

안전성 정보

• 픽토그램: GHS06,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H301,H314
• 예방조치 성명서: P260 - P280 - P301 + P310 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Skin Corr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges