재조합
expressed in E. coli (histidine-tagged)
분석
≥90% (SDS-PAGE)
양식
buffered aqueous solution
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... RNF11(26994)
생화학적/생리학적 작용
RNF11 (RING Finger Protein 11) is a RING E3 ubiquitin ligase with potential to mediate ubiquitination and subsequent proteolysis. RNF11 binds numerous proteins in a variety of cellular pathways, including TGFβ and EGFR signaling. RNF11 expression is elevated in breast and prostate cancer. RNF11 may represent an important target for novel cancer therapies.
물리적 형태
Solution in 50 mM Tris, pH 7.5, 150 mM NaCl, 1 mM DTT, and 30% glycerol (w/v).
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
Angelika Burger et al.
Neoplasia (New York, N.Y.), 8(8), 689-695 (2006-08-24)
Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways. RING E3 ligases promote the ubiquitination of proteins that are essential to
Michael K Connor et al.
Oncogene, 23(11), 2089-2095 (2004-03-17)
The identification of novel tumor-associated genes represents an important area of cancer research. To that end, we have discovered a number of genes whose expression is altered in breast tumors. One of these genes has been identified as the ring
Michael K Connor et al.
Molecular cancer research : MCR, 3(8), 453-461 (2005-08-27)
Ring finger proteins serve many vital functions within the cell. We have identified RNF11, a novel 154-amino acid ring finger-containing protein, which is elevated in breast cancer. Within its ring finger domain, RNF11 contains an AKT phosphorylation site (T135) that
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