PZ0374

PF-06446846 hydrochloride

≥98% (HPLC)

• 동의어(들): N-(3-Chloropyridin-2-yl)-N-((3R)-piperidin-3-yl)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
• 실험식(Hill 표기법): C₂₂H₂₀ClN₇O · xHCl
• CAS Number: 1632250-50-0
• Molecular Weight: 433.89 (free base basis)
• UNSPSC 코드: 41121800
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 광학 활성: [α]/D -60 to -50°, c = 1 in methanol
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 2 mg/mL, clear
• 저장 온도: room temp
• SMILES string: O=C(C1=CC=C(N2C(N=CC=C3)=C3N=N2)C=C1)N([C@H]4CNCCC4)C5=C(Cl)C=CC=N5

설명

생화학적/생리학적 작용

PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. PF-06446846 was found to reduce plasma PCSK9 and total cholesterol levels in rats.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3