생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
rat, human, mouse
기술
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... UNC93B1(81622)
일반 설명
Unc93b (unc-93 homolog B1) is a multiple membrane-spanning protein, that is located in the endoplasmic reticulum. It is mainly present in the heart and also highly expressed in dendritic cells and macrophages. It is located on chromosome 11q13.
면역원
a 19 amino acid peptide from near the amino-terminus of human Unc93b.
생화학적/생리학적 작용
Unc93b (unc-93 homolog B1) plays an important role in controlling the activation of TLRs (toll-like receptors). It also participates in the localization of TLR3 (toll-like receptor 3) to the surface of cell.
결합
The action of this antibody can be blocked using blocking peptide SBP4553.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men
European Journal of Heart Failure, 7(6), 958-965 (2005)
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
The Journal of Experimental Medicine, 206(6), 1339-1350 (2009)
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
The Journal of Biological Chemistry, 288(1), 442-454 (2013)
Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response
Human immunology, 68(11), 871-878 (2007)
hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein
Gene, 283(1-2), 209-217 (2002)
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