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Merck
모든 사진(3)

문서

PRS2221

Sigma-Aldrich

Anti-BAFF antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-BLyS, Anti-Tall, Anti-Thank, Anti-Tumor necrosis factor (ligand) superfamily, member 13b

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

predicted mol wt 31 kDa

종 반응성

human, rat, mouse

기술

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

일반 설명

B-lymphocyte activating factor (BAFF/TNFSF13B) is a cytokine that belongs to the TNF (tumor necrosis factor) superfamily. BAFF is located on human chromosome 13q33.

면역원

a peptide corresponding to amino acids near the carboxy-terminus of human BAFF.

생화학적/생리학적 작용

B cell activating factor (BAFF) participates in B cell and T cell mediated immunity. It plays a key role in the survival and differentiation of B cells. Mutations in BAFF regulates the levels of antibody. BAFF also participates in enhancing the responses of IL-6 (interlukin-6) and TNF-α (tumor necrosis factor alpha), that helps hepatocytes in the production of acute-phase protein.

결합

The action of this antibody can be blocked using blocking peptide SBP2221.

물리적 형태

Solution in phosphate buffered saline containing 0.02% sodium azide

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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관련 제품

제품 번호
설명
가격

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Polymorphism in the 5′ regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome.
Nossent JC, et al.
Rheumatology (Basel), 47(9), 1311-1316 (2008)
B cell-activating factor regulates the survival of B lymphocytes infected with human cytomegalovirus.
Xu H, et al.
Immunology Letters, 187, 1-6 (2017)
Association of genetic variation in B-cell activating factor with chronic hepatitis B virus infection.
Han Q, et al.
Immunology Letters, 188, 53-58 (2017)
Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case?control study.
Eilertsen G?, et al.
Rheumatology (Basel), 50(12), 2197-2205 (2011)
Sung-Sik Yoon et al.
International journal of molecular sciences, 22(13) (2021-07-21)
Fibroblast-like synoviocytes (FLSs) play a key role in the pathogenesis of rheumatoid arthritis (RA) by producing inflammatory cytokines and interacting with various immune cells, which contribute to cartilage destruction. RA-FLSs activated by tumor necrosis factor alpha (TNF-α), exacerbate joint damage

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