P9178

Prochlorperazine dimaleate salt

• 실험식(Hill 표기법): C₂₀H₂₄ClN₃S · 2C₄H₄O₄
• CAS Number: 84-02-6
• Molecular Weight: 606.09
• EC Number: 201-511-3
• MDL number: MFCD00069330
• UNSPSC 코드: 41116107
• PubChem Substance ID: 57654570
• NACRES: NA.77

속성

• 형태: powder
• solubility: H₂O: slightly soluble 0.3 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL; methanol: soluble
• 주관자: GlaxoSmithKline
• SMILES string: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1
• InChI: 1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChI key: DSKIOWHQLUWFLG-SPIKMXEPSA-N
• 유전자 정보: human ... DRD2(1813)

설명

생화학적/생리학적 작용

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; antispasmodic

특징 및 장점

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H336,H361d,H362
• 예방조치 성명서: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3
• 표적 기관: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves