P3487

Monoclonal Anti-PTEN antibody produced in mouse

~1 mg/mL, purified immunoglobulin, clone PTN-18, buffered aqueous solution

• 동의어(들): Anti-Mutated in multiple advanced cancers 1, Anti-PTEN1, Anti-PTENbeta, Anti-Phosphatase and tensin homolog, Anti-TEP1
• MDL number: MFCD02097285
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: PTN-18, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~55 kDa
• 종 반응성: mouse, human, rat
• 농도: ~1 mg/mL
• 기술: immunocytochemistry: suitable using 4% paraformaldehyde-0.5% Triton X-100 fixation; indirect ELISA: suitable; microarray: suitable; western blot: 5-10 μg/mL using whole extract of rat brain
• 동형: IgG2a
• UniProt 수납 번호: P60484
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... PTEN(5728) ; mouse ... Pten(19211) ; rat ... Pten(50557)

설명

일반 설명

The PTEN (phosphatase and tensin homolog) gene is mapped to human chromosome 10q23. It shares sequence homology with protein tyrosine phosphatases and the cytoskeletal protein tensin.

특이성

The epitope recognized by the antibody resides within amino acids 386-403 of rat PTEN.

면역원

synthetic peptide corresponding to the C-terminus of rat PTEN (amino acids 386-403).

생화학적/생리학적 작용

The PTEN (phosphatase and tensin homolog) gene encodes a encodes a dual-specificity phosphatase that functions as a tumor suppressor by inhibiting phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/PKB/Akt) signaling pathway, a crucial regulator of cell growth and survival and by negatively regulating the interactions of cell with the extracellular matrix. Mutations in this gene have been associated with several human cancers. Germline mutations in this gene have also been linked to Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), which are characterized by increased susceptibility to tumor formation and developmental defects.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable