P3360

Prostate Specific Antigen–α1-Antichymotrypsin Complex human

≥99% (SDS-PAGE), buffered aqueous solution

• 동의어(들): PSA-ACT
• CAS Number: 141176-92-3
• MDL number: MFCD00286324
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 분석: ≥99% (SDS-PAGE)
• 형태: buffered aqueous solution
• UniProt 수납 번호: P01011; P07288
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... KLK3(354) , SERPINA3(12)

설명

일반 설명

Kallikrein-3 (KLK3) or prostate specific antigen (PSA) is a serine protease. The protein contains a 371-residue N-terminal heavy chain, which is composed of four Apple domains. The PSA gene is localized to human chromosome 4q35. PSA is synthesized in the liver as a proenzyme known as prekallikrein. It is a key component of the kinin-generating pathways (PK system). The protein is involved in important physiological roles, such as blood pressure modulation, complement activation, and control and maintenance of inflammatory responses. KLK3b alleles are found to be associated with end-stage renal disease (ESRD) suggesting that variants in KLK3 gene might be linked with ESRD susceptibility.
SERPINA3 is also known as α-1-antichymotrypsin (ACT or AACT). The gene consists of five exons and is mapped to human chromosome 14q32.13. The protein contains 423 amino acids and belongs to the family of serpin superfamily of protease inhibitors. SERPINA3 inhibits the activity of pancreatic chymotrypsin, leukocyte, cathepsin G, mast cell chymases, human glandular, kallikrein 2 and kallikrein 3. Elevated expression of the protein has been observed in various types of carcinomas including breast carcinoma, hepatocellular carcinoma, prostate carcinoma and adenocarcinoma of the lung.

기타 정보

PSA from Human seminal fluid; Antichymotrypsin from human plasma

물리적 형태

Solution in 10 mM Sodium Acetate pH 5.6, 150 mM sodium chloride and 0.1% sodium azide.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable