P302-05

Porcine Pulmonary Artery Endothelial Cells: PPAEC (Cryovial)

• UNSPSC 코드: 41106514
• NACRES: NA.81

속성

• 생물학적 소스: Porcine pulmonary artery (Normal healthy)
• Quality Level: 100
• 형태: solid
• 포장: pkg of 500,000 cells
• 제조업체/상표: Cell Applications, Inc
• 성장 모드: Adherent
• 핵형: 2n = 38
• 형태학: Endothelial
• 기술: cell culture | mammalian: suitable
• 관련 질환(들): diabetes; cardiovascular diseases
• 배송 상태: dry ice
• 저장 온도: −196°C

설명

일반 설명

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PPAEC have been used in a pioneer study of endothelial cell motility, where it was determined that asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide production and a cardiovascular risk factor, decreased PKG-mediated phosphorylation of VASP, leading to downregulation of Rac1 and induction of stress fibers and focal adhesions via RhoA/ROCK dependent mechanism, leading to decreased cell motility, and increase in endothelial permeability, thus linking vascular repair and function with NO production (Wojciak-Stothard, 2007, 2009). PPAEC were also used to assess endothelial adhesion to decellularized porcine arteries in order to develop grafts for human vascular repair (Xiong, 2013).

세포주 기원

Artery

애플리케이션

cardiovascular function, screening of drug candidates, angiogenesis, vasodilator function, transport of deoxygenated bloood from heart to lungs

성분

Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO

제조 메모

• 1st passage, >500,000 cells in Porcine Endothelial Cell Growth Medium that contains 10% FBS and 10% DMSO
• Can be cultured at least 16 doublings

계대배양 정규 작업

Please refer to the PPAEC Culture Protocol.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable