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Merck
모든 사진(1)

문서

P2745

Sigma-Aldrich

Protein Phosphatase Inhibitor 1 human

동의어(들):

Inhibitor 1 human

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.77

생물학적 소스

human

Quality Level

재조합

expressed in E. coli

분석

>95% (SDS-PAGE)

형태

solution

분자량

~31 kDa
apparent mol wt ~27 kDa

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

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애플리케이션

This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies. Protein Phosphatase Inhibitor 1 human has been used as a component in the sucrose cell lysis buffer. It has also been used for intraperitoneal injection of mice prior to natterins or saline treatment in pharmacological intervention studies.

생화학적/생리학적 작용

Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.

물리적 형태

Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

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International journal of molecular medicine, 46(3), 1135-1145 (2020-07-25)
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Toxicon : official journal of the International Society on Toxinology, 87, 54-67 (2014-06-03)
Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in venules of mouse cremaster muscle using intravital microscopy. We reported that low doses of Natterins interfere with the cell

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