P0046

Pyocyanin

from Pseudomonas aeruginosa, ≥98% (HPLC), solid, redox-active phenazine

• 동의어(들): 5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin
• 실험식(Hill 표기법): C₁₃H₁₀N₂O
• CAS Number: 85-66-5
• Molecular Weight: 210.23
• MDL number: MFCD01794662
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329819996
• NACRES: NA.77

속성

• product name: Pyocyanin, from Pseudomonas aeruginosa, ≥98% (HPLC)
• 생물학적 소스: Pseudomonas aeruginosa
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: solid
• solubility: DMSO: soluble; acetone: soluble; chloroform: soluble; ethanol: soluble
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CN1c2ccccc2N=C3C(=O)C=CC=C13
• InChI: 1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3
• InChI key: YNCMLFHHXWETLD-UHFFFAOYSA-N

설명

애플리케이션

Pyocyanin has been used as a biomarker to detect Pseudomonas aeruginosa.

생화학적/생리학적 작용

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.

제조 메모

For the preparation of an aqueous solution, dissolve pyocyanin in ethanol using 10% of the final required volume and then add distilled water to complete the volume.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H319
• 예방조치 성명서: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable