P0026

Pilsicainide hydrochloride

≥98% (HPLC)

• 동의어(들): N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide hydrochloride, Pilzicainide hydrochloride, SUN 1165
• 실험식(Hill 표기법): C₁₇H₂₄N₂O · xHCl
• CAS Number: 88069-49-2
• Molecular Weight: 272.39 (free base basis)
• MDL number: MFCD00903769
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329819981
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: deionized water: >5 mg/mL
• 저장 온도: room temp
• SMILES string: Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3
• InChI: 1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
• InChI key: NZOSVDHCTCLGEB-UHFFFAOYSA-N

설명

애플리케이션

Pilsicainide hydrochloride has been used as a sodium channel blocker:

• to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
• to study its effects on Ca²⁺ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
• to study its electrophysiological effects on the guinea pig atrium

생화학적/생리학적 작용

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na⁺¹ channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(⁺) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

특징 및 장점

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안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable