O8014

Org 27569

≥98% (HPLC)

• 동의어(들): 5-Chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-ylphenyl)ethyl]amide
• 실험식(Hill 표기법): C₂₄H₂₈ClN₃O
• CAS Number: 868273-06-7
• Molecular Weight: 409.95
• EC Number: 278-169-7
• MDL number: MFCD11045300
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818922

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white
• solubility: H₂O: <2 mg/mL; DMSO: >5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc3ccc(cc3)N4CCCCC4
• InChI: 1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
• InChI key: AHFZDNYNXFMRFQ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Org 27569 is an allosteric modulator of CB₁ cannabinoid receptor.

Org 27569 is an allosteric modulator of CB₁ cannabinoid receptor. It significantly increases the binding of CB₁ receptor agonist [³H]-CP 55,940 (pK_B = 5.67) and causes a significant decrease in specific binding of CB₁ receptor inverse agonist SR141716A (Rimonabant; pK_B = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pK_B = 7.57 at CB₁ receptors in mouse vas deferens

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)