추천 제품
생물학적 소스
goat
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
lyophilized powder
종 반응성
mouse
기술
capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections
neutralization: 1-3 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt 수납 번호
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Spp1(20750)
일반 설명
The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.
면역원
purified recombinant mouse osteopontin expressed in NSO cells.
생화학적/생리학적 작용
Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.
물리적 형태
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
분석 메모
Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.
Ishigamori R, et al.
International Journal of Molecular Sciences, 18(5), 1058-1058 (2017)
Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice.
Lee S H, et al.
Oncotarget, 7(52), 87219-87219 (2016)
Tracking the embryonic stem cell transition from ground state pluripotency.
Kalkan T, et al.
Development, dev-142711 (2017)
Transcriptome analysis of fetal metatarsal long bones by microarray, as a model for endochondral bone formation.
Sugars R V, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1763(10), 1031-1039 (2006)
Mio Yamane et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10778-10800 (2020-07-04)
Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to the resultant fibrosis. An abnormal immune
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