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O0884

Monoclonal Anti-Oncostatin M antibody produced in mouse

Name: Monoclonal Anti-Oncostatin M antibody produced in mouse
Brand: SIGMA

clone 17001, purified immunoglobulin, lyophilized powder

동의어(들):

Anti-OSM

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

51111800

EC Number:

202-739-6

NACRES:

NA.41

MDL number:

MFCD01092430

Conjugate:

unconjugated

Clone:

17001, monoclonal

Application:

ELISA (i), Neutral, WB

Citations:

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

17001, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: suitable, neutralization: suitable, western blot: suitable

isotype

IgG2a

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 1

이 품목	I7901	SAB1402456	M2420
Sigma-Aldrich O0884 Monoclonal Anti-Oncostatin M antibody produced in mouse	Sigma-Aldrich I7901 Monoclonal Anti-Interleukin-6 antibody produced in mouse	Sigma-Aldrich SAB1402456 Monoclonal Anti-OSMR antibody produced in mouse	Sigma-Aldrich M2420 Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse
species reactivity human	species reactivity human	species reactivity human	species reactivity human
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone 17001, monoclonal	clone 6708.11, monoclonal	clone 3E12, monoclonal	clone 24822, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... OSM(5008)	Gene Information human ... IL6(3569)	Gene Information human ... OSMR(9180)	Gene Information human ... CCL2(6347)

General description

Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells. It also facilitates the LDL receptor expression and its uptake by hepatoma cells. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Immunogen

recombinant human OSM expressed in Escherichia coli.

Application

Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts.

J A Hamilton et al.

Biochemical and biophysical research communications, 180(2), 652-659 (1991-10-31)

Cytokine regulation of synovial cell function has been considered to be involved in the pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u-PA) expression may be relevant to the tissue remodelling, as well as to the cell migration and transformation

Regulation of IL-6 expression by oncostatin M.

T J Brown et al.

Journal of immunology (Baltimore, Md. : 1950), 147(7), 2175-2180 (1991-10-01)

Endothelial cells produce immunomodulatory cytokines in response to soluble mediators of inflammatory/immune reactions. We have previously demonstrated that the leukocyte-derived cytokine, oncostatin M (Onco M) can alter endothelial cell morphology, regeneration, and fibrinolytic activity in vitro. Here we demonstrate that

Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism.

R I Grove et al.

The Journal of biological chemistry, 266(27), 18194-18199 (1991-09-25)

Oncostatin M is a growth regulatory protein secreted by macrophages and activated T lymphocytes. In a hepatoma cell line (HepG2) the polypeptide very potently increased low density lipoprotein (LDL) uptake with an EC50 of 0.1-0.2 nM. The stimulation of LDL

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin.

T Kitamura et al.

Journal of cellular physiology, 140(2), 323-334 (1989-08-01)

We have established a novel cell line, designated as TF-1, from a patient with erythroleukemia, which showed complete growth dependency on granulocyte-macrophage colony-stimulating factor (GM-CSF) or on interleukin-3 (IL-3) and carried a homogeneous chromosomal abnormality (54X). Erythropoietin (EPO) also sustained

국제 무역 품목 번호

SKU	GTIN
O0884-.5MG	04061832715056

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