MTOXH1005

Cryopreserved Primary Human Hepatocytes Suspension

human liver (hepatocytes)

• 동의어(들): Primary Human Hepatocytes
• UNSPSC 코드: 12352207
• NACRES: NA.81

속성

• product name: Cryopreserved Primary Human Hepatocytes Suspension,
• 생물학적 소스: human liver (hepatocytes)
• 형태: liquid
• 포장: vial of ≥5 mil. cells
• 제조업체/상표: LifeNet Health^®
• 성장 모드: suspension
• 기술: cell culture | mammalian: suitable; genotyping: suitable
• 응용 분야: ADME/TOX
• 관련 질환(들): non-alcoholic steatohepatitis (NASH); non-alcoholic/simple fatty liver (NAFL)
• 배송 상태: liquid nitrogen
• 저장 온도: −196°C

설명

일반 설명

We provide high viability cryopreserved hepatocytes, sourced from LifeNet Health^® that predictably represents in vivo conditions. Applications for primary hepatocytes include in vitro evaluation of metabolism, drug-drug interaction, drug transporter activity, and toxicity of drug candidates. There are many other applications that encompass cryopreserved hepatocytes.

애플리케이션

See technical bulletins for detailed protocols.

Click lot availability link to get a complete list of currently available hepatocyte lots from LifeNet Health^®.

Once the lot number(s) of interest are determined enter the lot number into the “Certificate of Analysis” request search engine at the bottom of the page to obtain a pdf copy of the CoA. Note, lot number CoA upload is only available on the product number detail page corresponding with the lot number.

특징 및 장점

These cryopreserved hepatocytes are sourced from LifeNet Health^®. All cryopreserved hepatocytes have post-thaw viabilities over 80%. These lots are also characterized for Phase I CYP450 isoform and Phase II drug-metabolizing enzyme activity. Cryopreserved hepatocytes can be used for a variety of applications including metabolic stability, clearance, metabolite ID, metabolite profiling, species comparison studies, and uptake transporter studies.

Each lot is fully characterized for viability/stability, cell yield, attachment efficiency, optimal seeding density, monolayer confluency, Phase I and Phase II drug metabolizing enzyme activities and cyp induction. We have a wide selection of lots that can be used for a variety of applications, including, but not limited to:

• Drug metabolizing enzyme activity (stability, clearance, metabolite profiling and ID)
• Time-dependent metabolism (plated assay for low-clearance compounds)
• CYP450 Induction (mRNA and activity)
• Plated drug transporter assays (uptake and efflux)
• Toxicity assays
• High content analysis
• High content imaging
• 3D culture

포장

This product will be shipped in a liquid nitrogen dry shipper supplied from Cryoport. Please remember to ship the container back to Cryoport once you have removed the materials. Additional Cryoport shipping charges may apply.

Please see the Cryoport website for more details on the dry shipper.

법적 정보

LifeNet Health is a registered trademark of LifeNet Health

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable