M9073
Anti-Mitofusin 2 antibody,Mouse monoclonal
clone Mito-2, purified from hybridoma cell culture
동의어(들):
Anti-CMT2A, Anti-CMT2A2, Anti-CPRP1, Anti-HSG, Anti-Hyperplasia suppressor, Anti-KIAA0214, Anti-MARF, Anti-MFN2, Anti-Mitochondrial assembly regulatory factor, Anti-Transmembrane GTPase MFN2
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모든 사진(1)
About This Item
추천 제품
생물학적 소스
mouse
결합
unconjugated
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
Mito-2, monoclonal
형태
buffered aqueous solution
분자량
antigen ~86 kDa
종 반응성
mouse, rat
농도
~1.0 mg/mL
기술
western blot: 2-5 μg/mL using whole extract of rat brain mitochondria
동형
IgG1
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MFN2(9927)
일반 설명
Mitofusin-2 (MFN2) is an outer mitochondrial membrane protein.
Monoclonal Anti-Mitofusin 2 (mouse IgG1 isotype) is derived from the hybridoma Mito-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human Mitofusin 2 conjugated to KLH. Mitofusin 2ismammalian homolog of the Drosophila protein fuzzy onion (Fzo). It is a transmembrane GTPases embedded in the outer membrane of mitochondria. Mitofusin 2 is broadly expressed, with highest expression in heart and skeletal muscle and is induced during myogenesis.
애플리케이션
Anti-Mitofusin 2 antibody,Mouse monoclonal has been used in western blotting.
생화학적/생리학적 작용
Mitofusin 2 (Mfn2) mutant embryos have a specific and severe disruption of a layer of the placenta. Repression of Mfn2 causes morphological and functional fragmentation of the mitochondrial network into independent clusters and reduces mitochondrial membrane potential and glucose oxidation. Thus, this Mfn2-dependent regulatory mechanism is disturbed in obesity by reduced Mfn2 expression. Mutations in Mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, a neurological disorder that results from degeneration of axons in peripheral nerves.
Mitofusin-2 (MFN2) plays an important role as a mitochondrial fusion protein and controls many cell processes. It is mainly involved in regulating metabolic processes in the mitochondria. MFN2 prevents the formation of reactive oxygen species and controls endoplasmic reticulum stress. Mutations in the gene encoding this protein have been linked to diabetes and obesity.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Short-duration swimming exercise after myocardial infarction attenuates cardiac dysfunction and regulates mitochondrial quality control in aged mice
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
Nature Genetics, 36(5), 449-449 (2004)
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism A novel regulatory mechanism altered in obesity
The Journal of Biological Chemistry, 278(19), 17190-17197 (2003)
Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo
Journal of Cell Science, 115(8), 1663-1674 (2002)
The dynamics of cardiolipin synthesis post-mitochondrial fusion
Biochimica et Biophysica Acta - Biomembranes, 1798(8), 1577-1585 (2010)
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