M0199

Mdivi-1

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

• 동의어(들): 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
• 실험식(Hill 표기법): C₁₅H₁₀Cl₂N₂O₂S
• CAS Number: 338967-87-6
• Molecular Weight: 353.22
• MDL number: MFCD00974506
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329817738
• NACRES: NA.77

속성

• product name: Mdivi-1, ≥98% (HPLC), powder
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: >20 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
• InChI: 1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
• InChI key: NZJKEVWTYMOYOR-UHFFFAOYSA-N

설명

일반 설명

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

애플리케이션

Mdivi-1 has been used:

• in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation
• in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)
• to induce mitochondrial damage in lung fibroblasts

생화학적/생리학적 작용

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable