L9756

(−)-Tetramisole hydrochloride

powder, ≥99% (GC)

• 동의어(들): (S)-(−)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, L(−)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride, Levamisole hydrochloride
• 실험식(Hill 표기법): C₁₁H₁₂N₂S · HCl
• CAS Number: 16595-80-5
• Molecular Weight: 240.75
• Beilstein: 4358988
• EC Number: 240-654-6
• MDL number: MFCD00012675
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24278526
• NACRES: NA.77

속성

• product name: (−)-Tetramisole hydrochloride, ≥99% (GC)
• 생물학적 소스: synthetic (organic)
• 분석: ≥99% (GC)
• 형태: powder
• mp: 228-230 °C
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• 항생제 활성 스펙트럼: parasites
• 동작 모드: enzyme | inhibits
• SMILES string: Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3
• InChI: 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
• InChI key: LAZPBGZRMVRFKY-HNCPQSOCSA-N

설명

애플리케이션

Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor).
Intestinal alkaline phosphatases are only slightly inhibited.
Not for veterinary use.

생화학적/생리학적 작용

Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.

기타 정보

Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges