분석
~85% (TLC)
형태
crystalline
solubility
DMSO: soluble
methanol: soluble
저장 온도
−20°C
SMILES string
OC(=O)c1cc(ccc1O)N(Cc2ccccc2O)Cc3cc(O)ccc3O
InChI
1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28)
InChI key
ULTTYPMRMMDONC-UHFFFAOYSA-N
유전자 정보
human ... EGFR(1956) , ERBB2(2064) , LCK(3932)
생화학적/생리학적 작용
Cell-permeable tyrosine kinase inhibitor with little effect on protein kinase A or C. Inhibits NMDA-stimulated cGMP production. Inhibits VEGF-induced angiogenesis.
물리적 형태
Photosensitive
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
C C Huang et al.
The Journal of physiology, 520 Pt 3, 783-796 (1999-11-02)
1. Protein tyrosine phosphorylation is thought to play an important role in the regulation of neuronal function. Previous work has shown that protein tyrosine kinase (PTK) inhibitors can inhibit the induction of long-term potentiation (LTP), a candidate synaptic mechanism involved
D Spicarova et al.
Neuroscience, 166(1), 305-311 (2009-12-17)
Glutamate AMPA receptors are critical for sensory transmission at the spinal cord dorsal horn (DH). Plasma membrane AMPA receptor endocytosis that can be induced by insulin may underlie long term modulation of synaptic transmission. Insulin receptors (IRs) are known to
Kristin Löber et al.
Journal of cellular biochemistry, 103(4), 1076-1088 (2007-07-31)
The human mast cell line (HMC-1(560)) was used to study the effects of tyrosine kinase (TyrK) inhibition on histamine release in consequence of intracellular Ca2+ or pH changes. This is important since the TyrK inhibitor STI571 (Glivec) inhibits proliferation and
Shi-Sheng Zhou et al.
Experimental physiology, 92(3), 549-559 (2007-02-17)
The effects of monocarboxylic acid-derived Cl(-) channel blockers on cardiac depolarization-activated K(+) currents were investigated. Membrane currents in rat ventricular myocytes were recorded using the whole-cell configuration of the patch-clamp technique. 5-Nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) and niflumic acid (NFA) induced an
P Taskinen et al.
Endocrinology, 140(9), 4198-4207 (1999-08-28)
The cellular processes linking mechanical wall stretch to atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) secretion from the heart are unclear. In the present study, a paced perfused rat heart preparation was used to study the signaling mechanisms
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