J4205

JK184

≥98% (HPLC), powder

• 동의어(들): N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
• 실험식(Hill 표기법): C₁₉H₁₈N₄OS
• CAS Number: 315703-52-7
• Molecular Weight: 350.44
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329815733
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: off-white to light brown
• solubility: DMSO: ≥20 mg/mL
• 저장 온도: room temp
• SMILES string: CCOc1ccc(Cc2nc(cs2)-c3c(C)nc4ccccn34)cc1
• InChI: 1S/C20H19N3OS/c1-3-24-16-9-7-15(8-10-16)12-19-22-17(13-25-19)20-14(2)21-18-6-4-5-11-23(18)20/h4-11,13H,3,12H2,1-2H3
• InChI key: CBKFVRMNQUKWPX-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3