추천 제품
product name
Idebenone, ≥98% (HPLC)
분석
≥98% (HPLC)
형태
powder
solubility
methanol: 50 mg/mL, clear to slightly hazy
저장 온도
room temp
SMILES string
O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O
InChI
1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
InChI key
JGPMMRGNQUBGND-UHFFFAOYSA-N
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일반 설명
Idebenone is a short-chain benzoquinone drug.
애플리케이션
Idebenone has been used:
- to treat mutant myocilin (mMYOC) cells for drug treatment assay
- to validate C2C12 secondary cell screening assay
- to treat obese mice, to test whether idebenone and CoQ10 bind directly to peroxisome proliferator-activated receptor (PPAR)LBDs, His-tagged PPARα, δ and γ LBDs
생화학적/생리학적 작용
Idebenone is used in the treatment of visual impairment in adolescents and adults with Leber′s hereditary optic neuropathy (LHON). It serves as an antioxidant. It helps to guard the heart muscle against oxidative stress.
A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Idebenone: a review in Leber?s hereditary optic neuropathy
Lyseng-Williamson KA
Drugs, 76(7), 805-813 (2016)
In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles.
L Montenegro et al.
Journal of nanoscience and nanotechnology, 12(1), 330-337 (2012-04-25)
The aim of this study was to evaluate in vitro the permeation of the antioxidant agent Idebenone (IDE) loaded into solid lipid nanoparticles (SLN) across MDCKII-MDR1 cell monolayer, selected as an in vitro model of the Blood Brain Barrier (BBB).
Oliver Gamondi et al.
Drug metabolism letters, 6(2), 120-123 (2012-09-15)
We investigated the damage caused by oxidative stress using the yeast Saccharomyces cerevisiae as a model biological system. After inducing oxidative stress with menadione, we were able to evaluate the extent of cellular oxidative stress by utilizing 2',7'-dichlorofluorescein diacetate (DCFH-DA)
Carolyn P Ojano-Dirain et al.
The Laryngoscope, 122(11), 2543-2548 (2012-09-12)
Antioxidants have been shown to protect against aminoglycoside-induced hearing loss. Mitoquinone (MitoQ) is a mitochondria-targeted derivative of the antioxidant ubiquinone. MitoQ is attached to a lipophilic triphenylphosphonium (TPP) cation, which enables its accumulation inside the mitochondria several hundred-fold over the
Persistence of the treatment effect of idebenone in Leber's hereditary optic neuropathy.
T Klopstock et al.
Brain : a journal of neurology, 136(Pt 2), e230-e230 (2013-02-08)
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