추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
제품 라인
Prestige Antibodies® Powered by Atlas Antibodies
형태
buffered aqueous glycerol solution
종 반응성
human
기술
immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500
면역원 서열
PLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSRPSM
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... NKX6-1(4825)
관련 카테고리
일반 설명
NKX6-1 (NK6 homeobox 1), a homeobox transcription factor is coded by NKX6A gene. It is located on human chromosome 4q21.2-q22. NKX6-1 belongs to the NK homeobox gene family. It is specific in adult cells producing insulin.
면역원
NK6 homeobox 1 recombinant protein epitope signature tag (PrEST)
애플리케이션
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-NKX6-1 antibody has been used in immunofluorescence, FAIRE (formaldehyde-assisted isolation of regulatory elements) and ChIP and immunohistochemistry.
Anti-NKX6-1 antibody has been used in immunofluorescence, FAIRE (formaldehyde-assisted isolation of regulatory elements) and ChIP and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Chromatin immunoprecipitation (1 paper)
Chromatin immunoprecipitation (1 paper)
생화학적/생리학적 작용
NKX6-1 (NK6 homeobox 1) is involved in the growth and modulation of endocrine activities of pancreatic islets. It acts as an immunohistochemical marker for pancreatic and duodenal neuroendocrine tumors. NKX6-1 also participates in lineage specification in early pancreatic progenitor tissue. This gene regulates the expression of several pancreas-related genes.
특징 및 장점
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
결합
Corresponding Antigen APREST80893
물리적 형태
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
법적 정보
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Generation of thalamic neurons from mouse embryonic stem cells.
Shiraishi A, et al.
Development, 144, 1211-1220 (2017)
Minghui Wu et al.
Cell reports, 37(5), 109919-109919 (2021-11-04)
Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for increased insulin demand. Despite decades of research, the pathogenic mechanisms underlying T2D remain poorly defined. Here
Isolation, characterization, and chromosomal mapping of the human Nkx6. 1 gene (NKX6A), a new pancreatic islet homeobox gene.
Inoue H, et al.
Genomics, 40(2), 367-370 (1997)
Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6. 1 factors in IPC progenitors.
Walczak MP, et al.
Journal of Translational Medicine, 14(1), 341-341 (2016)
Duo An et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(2), E263-E272 (2017-12-28)
Cell encapsulation has been shown to hold promise for effective, long-term treatment of type 1 diabetes (T1D). However, challenges remain for its clinical applications. For example, there is an unmet need for an encapsulation system that is capable of delivering
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